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MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 ( HY-130614 ) and PROTAC EED degrader-2 ( HY-130615 ).
Appearance:Solid
In Vitro:MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI 50 of 14 nM for 14 days treatment. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Biological Activity:MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 ( HY-130614 ) and PROTAC EED degrader-2 ( HY-130615 ).