Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), this product is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The biological activity of 1-deoxyDHCer is not clearly understood at this time.N-C16-deoxysphinganine Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), is the N-acylated form of 1-deoxysphinganine,a potent inhibitor of sphingolipid metabolism. The N-acyl group can be 16, 20 and 24 carbon chain.N-acylsphinganines (dihydroceramides) are synthesized by the acylation of sphingoid bases in the presence of ceramide synthases (CerS).
规格
别名
N-C16-脱氧鞘氨醇
英文别名
N-C16-Deoxysphinganine | N-C16-1-deoxyDHCer
规格或纯度
Moligand™, ≥99%
英文名称
N-palmitoyl-1-deoxysphinganine (m18:0/16:0)
生化机理
N-acylsphinganines (dihydroceramides) levels are lower during ceramide synthase inhibition. They are intermediates of ceramide and dihydrosphingolipids synthesis. Treatment of MCF7 cancer cells with fenretinide alters sphingolipid metabolism.