An aryl sulphonamide that acts as a potent inhibitor of Ca2+-stimulated myosin S1 actin-stimulated ATPase activity (IC50 = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC50 = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC50<2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.
A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.
Ca 2+刺激的肌球蛋白S1 ATPase的选择性抑制剂（IC 50 =〜5 µM）。可逆地阻止滑行运动并减弱肌球蛋白与F-肌动蛋白的相互作用。Target IC50: ~5 µM against Ca2+-stimulated myosin S1 ATPase
Product does not compete with ATP.
Primary Target
Ca2+-stimulated myosin S1 ATPase
Cell permeable: no
Reversible: yes
D2315257
危险品化学品经营许可证（带存储）