N-甲基-D-天冬氨酸, GluN1 的激动剂;GluN2A 的激动剂;GluN2B 的激动剂;GluN2C 的激动剂;GluN2D 的激动剂

NMDA receptor Selective Antagonists

Moligand™

10mM in DMSO

CAS编号: 6384-92-5(DMSO)
分子式: C₅H₉NO₄
分子量: 147.13

有货

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
N407747-1ml	1ml	现货

查看相关系列

Compound libraries (12332)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

英文别名	D-Aspartic acid, N-methyl-
规格或纯度	Moligand™, 10mM in DMSO
英文名称	NMDA (N-Methyl-D-aspartic acid)
生化机理	NMDA（N-甲基-D-天冬氨酸）是 NMDA 受体的特异性激动剂，它模仿通常作用于该受体的神经递质谷氨酸的作用。第 4 阶段
储存温度	-80℃储存
运输条件	超低温冰袋运输
作用类型	激动剂
作用机制	GluN1 的激动剂;GluN2A 的激动剂;GluN2B 的激动剂;GluN2C 的激动剂;GluN2D 的激动剂
产品介绍	N-Methyl-D-Aspartic acid (NMDA) is a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. The NMDA receptor is a voltage-gated ion channel intimately involved in spatial learning and memory, and perturbing the normal behavior of this receptor system with NMDA exposure has facilitated elucidation of NMDA receptor-mediated activities. Information NMDA（N-Methyl-D-aspartic acid）is a specific agonist forNMDAreceptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4. In vitro NMDA is an excitatory amino acid neurotransmitter, which only binds to the NMDA receptor without effecting other glutamate receptors (such as those for AMPA and kainate). NMDA specifically binds to the NR2 subunits of NMDA receptor, and then stimulates the open of non-specific cation channel which can allow the passage of Ca²⁺ and Na⁺ into the cell and K⁺ out of the cell. Activation of the NMDA receptor is able to produce the excitatory postsynaptic potential (EPSP), and trigger the increase of intracellular Ca²⁺ content which may further take participating in various signaling pathways. NMDA receptor plays a key role in a wide range of physiological (e.g. long-term potentiation and neuronal plasticity) and pathological processes (e.g. excitotoxicity and epilepsy). In vivo Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥100%

产品属性

ALogP	-3.574
hba_count	2
HBD Count	1
Rotatable Bond	4

关联靶点（人）

HPN Tchem 丝氨酸蛋白酶 hepsin(Serine protease hepsin) (0 活性数据)

点击查看靶蛋白信息： HPN

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

名称和识别符

Canonical SMILES	CNC(CC(O)=O)C(O)=O
分子量	147.13
Reaxy-Rn	1724430
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1724430&ln=

化学和物理性质

溶解性	Solubility (25°C) In vitro DMSO: 58 mg/mL (199.81 mM); Ethanol: 15 mg/mL warmed with 50ºC Water: bath (51.67 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	5
DMSO(mM) Max Solubility	33.98
Water(mg / mL) Max Solubility	30
Water(mM) Max Solubility	203.9