| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N408414-1ml |
1ml |
现货  |
|
| 英文别名 | BRL-14777 | 2-Butanone, 4-(6-methoxy-2-naphthalenyl)- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Nabumetone |
| 生化机理 | 萘丁美酮（BRL-14777）是一种非甾体抗炎药，其活性代谢物可抑制 COX。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 环氧化酶-2 抑制剂 |
| 产品介绍 |
Nabumetone 是一种可口服的非酸类抗炎剂，为有效的、选择性的 COX-2 抑制剂，同时是活性代谢物 6MNA 的前体物质。 Information Nabumetone Nabumetone (BRL-14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX . Nabumetone is a nonsteroidal anti-inflammatory prodrug. Nabumetone itself is non-acidic and, following absorption, it undergoes extensive first-pass metabolism to form the main circulating active metabolite (6-MNA) which is a much more potent inhibitor of preferentially COX-2. In vivo Nabumetone displays acute anti-inflammatory activity in the carrageenan-induced oedema model in rats and the ultraviolet-induced erythema model in guinea-pigs. Its activity in these tests is greater than that of aspirin but less than that of naproxen and indomethacin. In the cotton pellet-induced granuloma model in the rat, Nabumetone is active and produces no signs of toxicity at doses much greater than the lowest effective dose, unlike aspirin, naproxen or indomethacin. Nabumetone is also active in the adjuvant-induced arthritis test in rats. In contrast to aspirin, indomethacin and naproxen, Nabumetone is well tolerated by the stomach of fasted rats at doses in excess of those with anti-inflammatory activity. cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 2.943 |
|---|---|
| hba_count | 2 |
| Rotatable Bond | 4 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | COC1=CC=C2C=C(CCC(C)=O)C=CC2=C1 |
| 分子量 | 228.29 |
| Reaxy-Rn | 2103472 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2103472&ln= |
| DMSO(mg / mL) Max Solubility | 46 |
|---|---|
| DMSO(mM) Max Solubility | 201.5 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 2103472 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2103472&ln= |
| Concentration(Compounding value) | 9-11(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
| 1. Lian Xu, Yan Xiao, Kun Yu, Hongshuo Pan, Jiayi Xu, Yiyun Guan, Mengke Wang, Xiangyu Xu, Hao Wang. (2025) Machine Learning-Assisted Chemical Tongues Based on Dual-channel Inclusion Complexes for Rapid Identification of Nonsteroidal Anti-inflammatory Drugs in Food. ACS Sensors, [PMID:39992799] [10.1021/acssensors.4c02806] |
| 1. Lian Xu, Yan Xiao, Kun Yu, Hongshuo Pan, Jiayi Xu, Yiyun Guan, Mengke Wang, Xiangyu Xu, Hao Wang. (2025) Machine Learning-Assisted Chemical Tongues Based on Dual-channel Inclusion Complexes for Rapid Identification of Nonsteroidal Anti-inflammatory Drugs in Food. ACS Sensors, [PMID:39992799] [10.1021/acssensors.4c02806] |
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