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Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC 50 s of 8.05, 9.83 and 0.57 μM for hMAO-B , NRF2 and QR2 . Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated m
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IC50& Target:IC 50 : 8.05 μM (hMAO-B), 9.83 μM (NRF2), 0.57 μM (QR2)
In Vitro:Nrf2-ARE/hMAO-B/QR2 modulator 1 (compound 4e) (100 μM; 24 hours) reduces the viability of SH-SY5Y cells by around 30%. Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 24 hours for pre-treatment, then coincubated for another 24 hours with 10 nM okadaic acid (O
Biological Activity:Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC 50 s of 8.05, 9.83 and 0.57 μM for hMAO-B , NRF2 and QR2 . Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated m