Retinol Binding Protein 4(RBP4) is thought to link obesity with insulin resistance and Type 2 Diabetes. Present in plasma of healthy individuals at a level of approximately 40 mg/L, RBP4 levels are higher in individuals with impaired glucose tolerance and Type 2 Diabetes. RBP4 levels are increased in pregnant women, especially those with gestational diabetes. Increased levels of RBP4 levels are also seen in individuals with cardiovascular disease, as RBP4 levels appear to correlate with levels of APO B-containing lipoproteins-- LDL, VLDL, and small dense LDL.
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
Aladdin products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.
规格
产品名称
视黄醇结合蛋白(RBP4) 来源于人血浆
英文别名
Retinol-binding protein 4 | retinol binding protein 4 | RBP4 | RDCCAS | MCOPCB10
规格或纯度
BioReagent, 天然, ≥95%(SDS-PAGE), 见COA
生化机理
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.
Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis. Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis. Ligand for receptor CD47. Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS. Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36. Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47. Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner. Ligand for immunoglobulin-like cell surface receptor SIRPA. Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA. Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging.
种属
人(Human)
来源
天然
预测分子量
21 kDa
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 50 mM Tris, 100 mM NaCl, pH 7.4
浓度
见COA
复溶
After centrifugation, we suggest addition of de-ionized H2O to the original volume (See COA), followed by gentle mixingto ensure adequate homogenization. If further dilution is required, please use lyophilization buffer.
ZJ25F1129505
危险品化学品经营许可证（带存储）