计算溶液所需的质量、体积或浓度。
蛋白酶3(PR3) 来源于人中性粒细胞
有货
概述
Extinction Coefficient: 1.0
Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation.
Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
规格
产品名称
蛋白酶3(PR3) 来源于人中性粒细胞
别名
成髓细胞素
英文别名
Myeloblastin | leukocyte proteinase 3 | proteinase 3 | Wegener's autoantigen | PRTN3 | MBN | MBT | NP4 | P29 | PR3 | ACPA | AGP7 | NP-4 | PR-3 | CANCA | C-ANCA
规格或纯度
生物活性,天然,≥95%(SDS-PAGE),见COA
生化机理
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. Plays a role in neutrophil transendothelial migration, probably when associated with CD177. Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation. Catalytic activity: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.Activity regulation: Inhibited by phenylmethanesulfonyl fluoride (PMSF) and diisopropyl fluorophosphate (DFP). pH Dependence: Optimum pH is 7.4.
种属
人(Human)
来源
天然
预测分子量
29 kDa
CAS编号和信息
128028-50-2
分子类型
酶
产品线
生物产品
储存与运输
物理形态
液体
储存缓冲液
50 mM MES, 700 mM NaCl, pH 4.5.
浓度
见COA
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
稳定性与储存
长期储存-80℃（大于1年）；收货后建议分装，避免反复冻融。
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ26F0231932 |
分析证书 | np001024 |
| ZJ26F0231933 |
分析证书 | np001024 |
技术文档和文章
溶液计算器
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