计算溶液所需的质量、体积或浓度。
血小板因子4 来源人血小板
有货
为什么选择此级别
冻干粉,天然,无叠氮钠,无载体 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Extinction Coefficient: 2.6
A heparin-neutralizing protein which is contained in platelet storage granules. Platelet Factor 4 is released during aggregation, but its actual role in normal or abnormal hemostasis is unknown.
Prepared from platelets shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.规格
产品名称
血小板因子4 来源人血小板
别名
血小板因子4,人血小板 | 天然人PF4蛋白
英文别名
Platelet Factor 4, Human Platelet | Human CXCL4 (PF4) Native Protein | Native human PF4 protein from the supernatant of thrombin-activated platelets | Native Human PF4 protein | PF4 | PF-4 | CXCL4 | SCYB4
规格或纯度
天然, 冻干粉, 无载体, 无叠氮钠, ≥95%(SDS-PAGE)
生化机理
Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. Chemotactic for neutrophils and monocytes via CCR1. Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis. In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity.
种属
人(Human)
无载体
Yes
来源
天然
预测分子量
7.8 kDa (monomer); 31.2 kDa (tetramer)
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS (pH 7.4, without stabilizers, without NaN₃).
复溶
Reconstitute in deionized water (1 μl/μg PF4). Adjust the protein concentration with PBS. Do not vortex.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20℃（12个月）；复溶后建议分装，避免反复冻融；避光；密封。
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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