The FC portion of the IgM molecule is important for structural studies and is thought to influence complement fixation and placental permeability.
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
规格
产品名称
免疫球蛋白 M，Fc5μ片段 来源于人血浆
别名
人 IgM Fc5μ 片段
英文别名
Human IgM Fc5μ | IgM Fc5mu, human | IGHM | MU | VH | AGM1
规格或纯度
BioReagent,天然,≥95%(SDS-PAGE),蛋白浓度: 见COA
生化机理
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Post-translational: N-glycosylated; important for IgM secretion and its localization at the plasma membrane. The interaction with FCMR is glycan-independent.
ZJ26F0434879
危险品化学品经营许可证（带存储）