Of the three haptoglobin phenotypes, Hp 1-1 is the most effective in binding free hemoglobin and in suppressing the inflammatory responses associated with free hemoglobin. Hp 1-1 protects against vascular complications in diabetes, is associated with sickle cell anemia, and is more common than other phenotypes in cases of cirrhosis.
Individuals who are phenotype 1-1 have the highest concentration of haptoglobin in plasma.
Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
规格
产品名称
结合珠蛋白,表型1-1 来源于人血浆
别名
人结合珠蛋白，表型 1-1
英文别名
Hp 1-1 | HP | BP | HPA1S | HP2ALPHA2
规格或纯度
BioReagent,天然,≥95%(SDS-PAGE),冻干前浓度：见COA
生化机理
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
种属
人(Human)
来源
天然
预测分子量
86 kDa
CAS编号和信息
9087-69-8
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from de-ionized water.
浓度
冻干前浓度：见COA
复溶
After centrifugation, we suggest addition of de-ionized H2O to the original volume (See COA), followed by gentle mixing to ensure adequate homogenization.
ZJ26F0333370
危险品化学品经营许可证（带存储）