An acute-phase reactant. Increased levels are associated with normal pregnancy, rheumatoid arthritis, and cirrhosis. Decreased levels are associated with hepatolenticular degeneration (Wilson's Disease). An elevated level of Cp is found in patients with progressive tumors. Additionally, as Cp is a prooxidant, an elevated level is a sign of cardiovascular disease. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Handling: Following reconstitution, store at 4℃. Avoid freeze-thaw cycles, as this will contribute to protein breakdown. Exposure to sodium (in the form of sodium chloride, sodium phosphate, sodium azide, as well as other sodium containing reagents) should be avoided, as ceruloplasmin may precipitate under these conditions. Buffers that ceruloplasmin is exposed to should bepH-adjusted with potassium hydroxide.
Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu+ oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis.
种属
人(Human)
来源
天然
预测分子量
132 kDa
CAS编号和信息
9031-37-2
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 50 mM Potassium phosphate, 100 mM KCl, 20 mM E-amino-n-caproic acid, 5 mM EDTA, pH 6.8.
复溶
After centrifugation, we suggest addition of de-ionized H2O to the original volume, followed by gentle mixing to ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.