C4b-binding protein is a regulatory protein of the Complement Cascade that possesses decay-accelerating activity. Circulating in plasma, it aids in the control of fluid-phase and surface-associated activation of C3 and C5 and serves as a cofactor to Factor 1 in the proteolytic degradation of C4b. There are three isoforms circulating in plasma; 7 alpha chains and 1 Beta chain, 6 alpha chains and 1 Beta chain, and 7 alpha chains without a Beta chain. The 7 alpha, 1 Beta form is the most abundant. All C4BP molecules that contain a Beta chain circulate in plasma in a high-affinity, calcium-dependent complex with vitamin K-dependent, anticoagulant Protein S. C4b-binding protein has been investigated for its role in Alzheimer's Disease, Psoriasis, as well as autoimmune diseases including Rheumatoid Arthritis, and different types of Cancer. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Free of Protein S.
规格
产品名称
C4b-结合蛋白 来源于人血浆
别名
C4b结合蛋白
英文别名
C4b-binding protein alpha chain | C4bp | C4bpa | C4BPA_HUMAN | Complement component 4 binding protein | Complement component 4 binding protein alpha | Proline-rich protein | PrP | C4b binding protein beta chain | C4b-binding protein beta chain | C4BPB | C
规格或纯度
BioReagent, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration
生化机理
C4BPA: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It also interacts with anticoagulant protein S and with serum amyloid P component. C4BPB: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
Lyophilized from 10 mM Tris, 100 mM NaCl, 0.05% NaN3, pH 7.4.
浓度
Pre-lyophilization Protein Concentration
复溶
After centrifugation, we suggest addition of de-ionized H2O to the original volume (See COA), followed by gentle mixingto ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.
ZJ25F0825193
危险品化学品经营许可证（带存储）