C-Reactive Protein (CRP) is a homopentameric protein with a monomer size of ~24 kDa. It is a member of the pentraxin family, a family of proteins characterized by their calcium dependent ligand binding and unique ring-like structure. Like many other pentraxins, CRP is highly upregulated in the acute-phase response to bodily insults such as tissue injuries, infections and general inflammation. In normal, healthy individuals the concentration of CRP in blood is ~5 mg/ml. This number rises 5-10 fold in response to infection or other causes of inflammation. In severe cases, CRP levels can rise above 200 mg/L. CRP can be used as a biomarker for general inflammation or more specific issues such as certain cancers, diabetes, hypertension, cardiovascular disease (CVD) or Rheumatoid Arthritis (RA). On a cellular/molecular level, CRP activates the complement system of the immune response by binding to surface molecules on dead/dying cells or foreign/invading bacteria. Laboratories and companies investigating the diseases mentioned, complement system induction or the acute phase would find our CRP a useful reagent in their studies. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Aladdin products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.
规格
产品名称
C反应蛋白 来源于人血浆
别名
C-反应蛋白
英文别名
C-Reactive Protein | Pentraxin 1, short | C reactive protein | C reactive protein pentraxin related | C-reactive protein(1-205) | CRP | CRP_HUMAN | MGC88244 | Pentraxin 1 | PTX 1 | PTX1
规格或纯度
BioReagent, ≥95%(SDS-PAGE), 见COA
生化机理
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
ZJ25F1129333
危险品化学品经营许可证（带存储）