载脂蛋白 B 是低密度脂蛋白（LDL）中最主要的蛋白质成分。在正常血浆中，载脂蛋白 B 的浓度为每 100 毫升 90 毫克。载脂蛋白 B 的作用被认为包括：稳定脂质乳剂、充当酶促反应的辅因子与调节剂、协助脂质排出细胞外，以及将脂质转运至靶器官。载脂蛋白 B 水平与冠心病风险呈正相关。相较于低密度脂蛋白（LDL）水平，载脂蛋白 B 水平可能是更灵敏的心血管疾病风险预测指标，且其准确检测无需空腹。 载脂蛋白 B 存在两种形式，分别是载脂蛋白 B-100（Apo B-100）和载脂蛋白 B-48（Apo B-48）： 载脂蛋白 B-100 存在于极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）中，由肝脏合成；
载脂蛋白 B-48 存在于乳糜微粒（chylomicrons）中，起源于肠道。 所用血浆经 FDA 要求的检测显示，乙型肝炎表面抗原（HBsAg）、抗丙型肝炎病毒（抗 - HCV）、抗乙型肝炎核心抗体（抗 - HBc）均为阴性，且抗人类免疫缺陷病毒 1 型和 2 型（抗 - HIV 1 & 2）也为阴性。
Apolipoprotein B is the dominant protein constituent of LDL. The concentration of Apo B in normal plasma is 90 mg per 100 ml. Apo B is thought to stabilize lipid emulsions, serve as a cofactor and modulator of enzymatic reactions, manage export of lipids out of cells and direct lipids to target organs. Apo B levels are positively correlated with the risk of coronary disease. Apo B levels may be a more sensitive predictor of cardiovascular risk than LDL levels and do not involve fasting for accurate measurement. Two forms of Apo B exist: Apo B-100 and Apo B-48. The first is found in VLDL and LDL and is produced by the liver. The second is found in chylomicrons and originates in the intestine. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
BioReagent, 天然, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration
生化机理
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
Post-translational: Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.
种属
人(Human)
来源
天然
预测分子量
550 kDa
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 10 mM Na deoxycholate, 50 mM Na2CO3, 50 mM NaCl, pH 10.0.
浓度
Pre-lyophilization Protein Concentration
复溶
After centrifugation, we suggest addition of de-ionized H2O to the original volume (See COA), followed by gentle mixingto ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.
ZJ25F1129658
危险品化学品经营许可证（带存储）