α2巨球蛋白，人血浆，快速型

功能和特点

有货

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货号 (SKU)	包装规格	是否现货	价格	数量
np001157-100μg	100μg	期货
np001157-500μg	500μg	期货

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人类蛋白质 (118)

基本描述

产品名称	α2巨球蛋白，人血浆，快速型
规格或纯度	≥95%(SDS-PAGE), Extinction Coefficient: 0.81
产品介绍	Bulk Qty Available. Alpha 2 Macroglobulin (A2M) is a plasma protease inhibitor which has been shown to exist in two forms. The Slow Form of A2M (S-A2M) is the form which possesses the ability to bind and inhibit proteases by a “trap” method. The Fast Form of A2M (F-A2M) is generated when S-A2M undergoes a conformational change due to either entrapment of a protease in the A2M bait region, or chemical cleaveage of an internal thiol ester bond located near the bait region. F-A2M does not possess the ability to bind and inhibit protease activity. F-A2M is rapidly taken up by the liver, with a half life of 2-4 minutes. In vivo, F-A2M typically represents only 0.17–0.7% of the total A2M in blood plasma of adults. The F-A2M plasma concentration is, however, increased in many disease states including pancreatitis, multiple sclerosis and sepsis. F-A2M has also been implicated in the inhibition of amyloid formation associated with Alzheimer’s disease and spongiform encephalopathies. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
预测分子量	725000

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 100 mM Na Phosphate, pH 7.2
浓度	Extinction Coefficient: 0.81
储存温度	-20°C储存
运输条件	超低温冰袋运输
分子类型	蛋白质