Purified Native Human Alpha 2 Macroglobulin, Human Plasma A major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. Aladdin products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research use only.
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
种属
人(Human)
来源
天然
预测分子量
725 kDa
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 30 mM Na Phosphate, 1 mg Glycine per 1 mg Alpha 2 Macroglobulin, pH 7.0.
浓度
Extinction Coefficient: 0.81
复溶
After centrifugation, we suggest addition of de-ionized H2O to the original volume, followed by gentle mixingto ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.
ZJ26F0737376
危险品化学品经营许可证（带存储）