急性期血浆蛋白含量为每100毫升45毫克。ACT作为胰凝乳蛋白酶样丝氨酸蛋白酶的特异性抑制剂发挥作用。临床上，它在炎症、一些恶性肿瘤、克罗恩病、溃疡性结肠炎和烧伤中升高。PSA-ACT复合物水平被认为是癌症前列腺的生物标志物。 消光系数：0.6 所用血浆经 FDA 要求的检测显示，乙型肝炎表面抗原（HBsAg）、抗丙型肝炎病毒（抗 - HCV）、抗乙型肝炎核心抗体（抗 - HBc）均为阴性，且抗人类免疫缺陷病毒 1 型和 2 型（抗 - HIV 1 & 2）也为阴性。
An acute-phase plasma protein found at 45 mg per 100 ml. ACT functions as a specific inhibitor of chymotrypsin-like serine proteases. Clinically, it is elevated in inflammatory conditions, some malignancies, Crohn's disease, ulcerative colitis, and burn injuries. The PSA-ACT complex level is considered a biomarker for prostate cancer. Extinction Coefficient: 0.6 Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
BioReagent, 天然, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration
生化机理
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Post-translational: N- and O-glycosylated.
种属
人(Human)
来源
天然
预测分子量
64 kDa
CAS编号和信息
141176-92-3
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 20 mM Tris, with 150 mM NaCl, pH 7.4.
浓度
Pre-lyophilization Protein Concentration
复溶
After centrifugation, we suggest addition of de-ionized H2O to the original volume (See COA), followed by gentle mixingto ensure adequate homogenization. If further dilution is required, please use the lyophilization buffer.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20℃（5年）；复溶后建议分装，避免反复冻融。
图片
Alpha 1 Antichymotrypsin from Human Plasma (np001162) - SDS-PAGE
2 μg/lane of Alpha 1 Antichymotrypsin from Human Plasma was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 60 kDa.
ZJ25F1028299
危险品化学品经营许可证（带存储）