计算溶液所需的质量、体积或浓度。
提供 ≥97% 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存,干燥。超低温运输 。请查阅批次 COA 获取详细规格。
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
ODN 2216 is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-α and IFN-β . ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4 + T cells
In Vitro
ODN 2216 (6 μg/mL, 9 days) drives Th1 development of naive CD4 T cells. ODN 2216 (2 μM, 15 h) significantly decreased apoptosis of thymic DC. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Thymic DC, pDC Concentration: 2 μM Incubation Time: 15 h Result: Significantly decreased apoptosis of thymic DC (23.1 ± 0.9%), and naturally induced apoptosis of thymic pDC was not decreased (72.8 ± 2.9%).
In Vivo
ODN 2216 induces T-cell mediated antitumor immune response in murine vaccination modelsMCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:TLR9 IL-12