D2518387计算溶液所需的质量、体积或浓度。
11-氧代罗汉果苷V
有货
为什么选择此级别
Moligand™ 级 提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,避光。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
11-oxo-mogroside V is a natural sweetener that exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species ( O 2 - , H 2 O 2 and *OH ) with EC 50 of 4.79, 16.52, and 146.17 μg/mL, respectively.
In Vitro
11-oxo-mogroside V shows a higher scavenging effect on O 2 - (concentration at which 50% of chemiluminescence intensity is inhibited [EC 50 ]=4.79 μg/mL) and H 2 O 2 (EC 50 =16.52 μg/mL) than those of mogroside V. 11-oxo-mogroside V exhibits a remarkable inhibitory effect on *OH-induced DNA damage with EC 50 =3.09 μg/mL.11-oxo-mogroside V, a natural sweetener, isolated from the fruits of Momordica grosvenori , exhibits strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-oxo-mogroside V exhibits strong inhibitory effect on EBV-EA induction (91.2, 50.9 and 21.3% inhibition at 1000, 500 and 100 mol ratio/TPA concentration, respectively). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In the group treated with DMBA, TPA and 11-oxo-mogroside V, only 26.6 and 53.3% of mice bore papillomas even at 10 and 15 weeks of promotion, respectively, and only 1.0 3.3 and 4.7 papillomas are formed per mouse at 10, 15 and 20 weeks of promotion. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal administration
Mice Specific pathogen-free female ICR (6 weeks old) and female SENCAR (6 weeks old) mice are use. The animals (female SENCAR, 6 weeks old) are divided into three groups, 15 mice each. The back of each mouse is shaved with surgical clipper, and the mice are topically treated with peroxynitrite (33.1 μg, 390 nmol, 1 mM NaOH) in acetone (0.1 mL) as an initiation treatment. For groups I (control group) II and III, 1 week after initiation with peroxynitrite, mice are promoted by the application with TPA (1 mg, 1.7 nmol) in acetone (0.1 mL) twice a week. For groups II and III, mogroside V and 11-oxo-mogroside V (0.0025%, 2.5 mg/100 mL) in drinking water is given orally, from 1 week before to 1 week after the initiation treatment with peroxynitrite, respectively. The incidence of papillomas is observed weekly for 20 weeks; the percentages of mice bearing papillomas and the average number of papillomas per mouse are recorded. The type of tumors in our experiment is also checked by the pathologist with the histological examination, and the malignant tumors are not observed at 20 weeks of promotion in our experimental system. The tumor incidence is statistically analyzed by Student's t-test in treated mice and controls. aladdin has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:EC50: 4.79 μg/mL (O 2 - ), 16.52 μg/mL (H 2 O 2 ), 146.17 μg/mL (*OH)
规格
别名
11-氧代罗汉果苷V | 11-氧-罗汉果皂甙V
规格或纯度
Moligand™, ≥99%
英文名称
11-oxo-mogroside V
生化机理
11-oxo-mogroside V 是一种天然甜味剂，具有很强的抗氧化活性。它对活性氧（O 2 -、H 2 O 2 和 *OH ）有明显的抑制作用，EC 50 分别为 4.79、16.52 和 146.17 μg/mL。
储存条件
2-8°C储存,避光
运输条件
低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
PubChem SID
分子类型
小分子
IUPAC Name
(3S,8S,9R,10R,13R,14S,17R)-17-[(2R,5R)-5-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-hydroxy-6-methylheptan-2-yl]-4,4,9,13,14-pentamethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-11-one
INCHI
1S/C60H100O29/c1-23(9-13-35(57(4,5)79)88-55-50(89-54-49(78)43(72)38(67)29(20-63)84-54)45(74)40(69)31(86-55)22-81-52-47(76)42(71)37(66)28(19-62)83-52)24-15-16-58(6)32-12-10-25-26(60(32,8)33(64)17-59(24,58)7)11-14-34(56(25,2)3)87-53-48(77)44(73)39(68)30(85-53)21-80-51-46(75)41(70)36(65)27(18-61)82-51/h10,23-24,26-32,34-55,61-63,65-79H,9,11-22H2,1-8H3/t23-,24-,26-,27-,28-,29-,30-,31-,32+,34+,35-,36-,37-,38-,39-,40-,41+,42+,43+,44+,45+,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,58+,59-,60+/m1/s1
InChi Key
CGGWHBLPUUKEJC-YMWSYRNLSA-N
Smiles
CC(CCC(C(C)(C)O)OC1C(C(C(C(O1)COC2C(C(C(C(O2)CO)O)O)O)O)O)OC3C(C(C(C(O3)CO)O)O)O)C4CCC5(C4(CC(=O)C6(C5CC=C7C6CCC(C7(C)C)OC8C(C(C(C(O8)COC9C(C(C(C(O9)CO)O)O)O)O)O)O)C)C)C
分子量
1285.42
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 脂质和脂质样分子 |
| 类（Class) | 类固醇和类固醇衍生物 |
| 亚类（Subclass） | 甾体糖苷 |
| 中间层级节点（Intermediate Tree Nodes） | 甾体皂苷 |
| 直接上位类(Direct Parent) | 葫芦素苷 |
| 其他上位类（Alternative Parents） | 三萜类化合物 葫芦素 寡糖 11-氧代类固醇 14-α-甲基类固醇 羟基类固醇 Delta-5-类固醇 烷基糖苷 O-糖基化合物 氧烷 叔醇 酮类 仲醇 氧环化合物 多元醇 缩醛 碳氢化合物衍生物 伯醇 有机氧化物 |
| 分子骨架（Molecular Framework) | 脂肪族杂多环化合物 |
| 取代基（Substituents） | 11-羰基类固醇 - 14-α-甲基类固醇 - 25-羟基类固醇 - 乙醛酸 - 羟基苯甲酸酯 - 脂肪族杂多环化合物 - 烷基苷 - 羰基 - 苷元结构 - 苷元 - Delta-5-类固醇 - 脂肪酰基 - 脂肪酰基糖苷 - 糖基化合物 - 烃衍生物 - 酮 - O-羧基化合物 - 萜类化合物 - 有机氧化物 - 有机氧化合物 - 有机杂环化合物 - 有机氧化合物 - 氧杂环 - 氧杂环丁烷 - 氧甾类 - 多醇 - 初级醇 - 醛基 - 三烷基醇 - 三萜类化合物 |
| 描述（Description） | 该化合物属于葫芦素苷类有机化合物。这类多环化合物通过糖苷键将碳水化合物衍生物连接至葫芦烷骨架。 |
| 外部描述符（External Descriptors） | 暂无 |
三维结构
交互式化学结构模型
化学和物理性质
溶解性
DMSO : 100 mg/mL (77.80 mM; Need ultrasonic)
敏感性
对光线敏感
分子量
1285.400 g/mol
XLogP3
-4.000
氢键供体数Hydrogen Bond Donor Count
18
氢键受体数Hydrogen Bond Acceptor Count
29
可旋转键计数Rotatable Bond Count
20
精确质量Exact Mass
1284.64 Da
单同位素质量Monoisotopic Mass
1284.64 Da
拓扑极表面积Topological Polar Surface Area
474.000 Ų
重原子数Heavy Atom Count
89
形式电荷Formal Charge
0
复杂度Complexity
2410.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
34
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
质检证书（CoA,COO,BSE/TSE 和分析图谱)
溶液计算器
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