PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC -based and dual AR, AR-V7 degrader, with DC 50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker).