PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL , with a D max >90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide -linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.