Poneratoxin acetate is the acetate salt form of Poneratoxin. Poneratoxin acetate is the modulator for voltage-gated sodium channel ( NaV , EC 50 for NaV1.6 and NaV1.6 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals.