PROTAC α-synuclein degrader 6 (compound T3) isa PROTAC degrader of α-synuclein and tau , with EC 50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-synuclein degrader 6 plays an important role in neurodegenerative diseases (NDs) research (Blue:ubiquitin E3 ligase cereblon ligand , Black: linker ; Pink: Ligand for target protein ).