PROTAC α-synuclein degrader 5 is a highly selective small-molecule degraders ( PROTAC ) of α-synuclein aggregates, with an DC 50 of 7.51 μM and the highest degradation rate D max of 89%. PROTAC α-synuclein degrader 5 contains probe molecule sery308 and E3 ligase ligands. PROTAC α-synuclein degrader 5 can be used for neurological disease research.