Paraformaldehyde-Glutaraldehyde Mixed Fixative (4%/1%) is a classic aldehyde-based mixed fixative specifically designed for electron microscopy (transmission electron microscopy) sample preparation. This fixative is composed of 4% paraformaldehyde and 1% glutaraldehyde in phosphate buffer (pH ~7.4). Its core advantage lies in combining the excellent membrane penetration of paraformaldehyde with the rapid and stable crosslinking capability of glutaraldehyde for protein ultrastructure. The increased glutaraldehyde concentration (compared to the 0.5% formulation) further enhances crosslinking fixation of cellular ultrastructure, making it more suitable for electron microscopy samples requiring high structural preservation. It effectively prevents autolysis and maximally preserves the native state of organelles and subcellular structures. It should be noted that this fixative is primarily directed at protein fixation and is therefore not suitable for fixing nucleic acids or polysaccharides.
危险品化学品经营许可证（带存储）