计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
室温,充氩。常规运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 101 篇同行评审文献引用。
概述
聚乳酸（PLA）是一种可生物降解的聚酯 由乳酸单体通过开环聚合合成。 由于其优异的热力学、机械和阻隔性能，它被 广泛应用于组织工程，药物输送和骨科 装置。
规格
别名
聚(2-羟基丙酸) | (±)-乳酸均聚物
英文别名
DL-Lactic acid, ~90% (T) | E-270 | Ethylidenelactic acid | INS NO.270 | Lacticum acidum | 33X04XA5AT | Biolac | DL-Lactic acid | CHEBI:78320 | Kyselina mlecna | Cheongin Haewoohwan | L-lactic acid or dl-lactic acid | (+-)-LACTIC ACID | 1-hydroxyethane car
规格或纯度
Mw ~60,000
英文名称
Polylactic acid(PLA)
应用
聚乳酸可以通过静电纺丝法制备成管状支架。这些支架适用于血管组织工程。
它可通过静电纺丝和涂布法制备成聚乳酸/聚乙烯醇创伤敷料膜。 PLA涂层提高了纳米纤维的机械强度，并作为保护层控制药物向伤口部位的释放。
它还可用于合成独立的，柔性的，超薄PLA纳米薄膜，可作为骨骼肌细胞粘附、扩散和增殖的基质。
储存条件
室温,充氩
运输条件
常规运输
名称和识别符
PubChem SID
EC号
825-250-5
分子类型
聚合物
IUPAC Name
2-hydroxypropanoic acid
INCHI
1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)
InChi Key
JVTAAEKCZFNVCJ-UHFFFAOYSA-N
Smiles
CC(C(=O)O)O
Isomeric SMILES
CC(C(=O)O)O
Reaxy-Rn
1209341
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1209341&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
-
界（kingdom)
有机化合物
-
超类（Superclass)
有机酸及其衍生物
-
类（Class)
羟基酸及其衍生物
- 亚类（Subclass） α-羟基酸及其衍生物
-
类（Class)
羟基酸及其衍生物
-
超类（Superclass)
有机酸及其衍生物
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机酸及其衍生物 |
| 类（Class) | 羟基酸及其衍生物 |
| 亚类（Subclass） | α-羟基酸及其衍生物 |
| 中间层级节点（Intermediate Tree Nodes） | 暂无 |
| 直接上位类(Direct Parent) | α-羟基酸及其衍生物 |
| 其他上位类（Alternative Parents） | 仲醇 一元羧酸及其衍生物 羧酸 有机氧化物 碳氢化合物衍生物 羰基化合物 |
| 分子骨架（Molecular Framework) | 脂肪族无环化合物 |
| 取代基（Substituents） | 羟基苯甲酸酯 - 脂肪族非环化合物 - α-羟基酸 - 羰基 - 羧酰胺基 - 羧酸衍生物 - 烃衍生物 - 单羧酸或其衍生物 - 有机氧化物 - 有机氧化合物 - 有机氧化合物 - 醛基 |
| 描述（Description） | 该化合物属于α-羟基酸及其衍生物类有机化合物。这类化合物含有羧基，其相邻碳原子被羟基取代。 |
| 外部描述符（External Descriptors） | 2-hydroxy monocarboxylic acid |
三维结构
交互式化学结构模型
产品属性
| ALogP | -0.7 |
|---|
关联靶点（人）
PDE5A
Tclin
Phosphodiesterase 5A
(5113 活性数据)
EGFR
Tclin
Epidermal growth factor receptor erbB1
(33727 活性数据)
CA2
Tclin
Carbonic anhydrase II
(17698 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
HMGCR
Tclin
HMG-CoA reductase
(2475 活性数据)
NR3C1
Tclin
Glucocorticoid receptor
(14987 活性数据)
INSR
Tclin
Insulin receptor
(5558 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
ADRB2
Tclin
Beta-2 adrenergic receptor
(11824 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
ADRB1
Tclin
Beta-1 adrenergic receptor
(6630 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
ACE
Tclin
Angiotensin-converting enzyme
(1423 活性数据)
DRD2
Tclin
Dopamine D2 receptor
(23596 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
CNR1
Tclin
Cannabinoid CB1 receptor
(20913 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
DRD4
Tchem
Dopamine D4 receptor
(7907 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
HRH2
Tclin
Histamine H2 receptor
(5428 活性数据)
ADRA1D
Tclin
Alpha-1d adrenergic receptor
(4171 活性数据)
HTR1B
Tclin
Serotonin 1b (5-HT1b) receptor
(2801 活性数据)
HTR2A
Tclin
Serotonin 2a (5-HT2a) receptor
(14758 活性数据)
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor
(11471 活性数据)
ADORA1
Tclin
Adenosine A1 receptor
(17603 活性数据)
CALCR
Tclin
Calcitonin receptor
(2215 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
HRH1
Tclin
Histamine H1 receptor
(7573 活性数据)
ADRA1B
Tclin
Alpha-1b adrenergic receptor
(2912 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
AVPR1A
Tclin
Vasopressin V1a receptor
(5412 活性数据)
OPRD1
Tclin
Delta opioid receptor
(15096 活性数据)
OPRK1
Tclin
Kappa opioid receptor
(16155 活性数据)
SLC6A3
Tclin
Dopamine transporter
(10535 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
HTR4
Tclin
Serotonin 4 (5-HT4) receptor
(2068 活性数据)
ESR2
Tclin
Estrogen receptor beta
(9272 活性数据)
CYSLTR1
Tclin
Cysteinyl leukotriene receptor 1
(2118 活性数据)
ERBB2
Tclin
Receptor protein-tyrosine kinase erbB-2
(7851 活性数据)
CHRM4
Tclin
Muscarinic acetylcholine receptor M4
(6041 活性数据)
CHRM5
Tclin
Muscarinic acetylcholine receptor M5
(4677 活性数据)
ADRA2B
Tclin
Alpha-2b adrenergic receptor
(4412 活性数据)
关联靶点（其它种属）
Agtr2
Angiotensin II type 2 (AT-2) receptor (803 活性数据)
Mc4r
Melanocortin receptor 4 (1205 活性数据)
Ltc4s
Leukotriene C4 synthase (1 活性数据)
Sigmar1
Sigma opioid receptor (160 活性数据)
Npy1r
Neuropeptide Y receptor type 1 (8 活性数据)
Cckar
Cholecystokinin A receptor (90 活性数据)
Nos2
Nitric oxide synthase, inducible (3573 活性数据)
Mapk1
MAP kinase ERK2 (650 活性数据)
Mmp9
Matrix metalloproteinase 9 (38 活性数据)
Glra2
Glycine receptor (1745 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
敏感性
对湿度敏感
分子量
90.080 g/mol
XLogP3
-0.700
氢键供体数Hydrogen Bond Donor Count
2
氢键受体数Hydrogen Bond Acceptor Count
3
可旋转键计数Rotatable Bond Count
1
精确质量Exact Mass
90.0317 Da
单同位素质量Monoisotopic Mass
90.0317 Da
拓扑极表面积Topological Polar Surface Area
57.500 Ų
重原子数Heavy Atom Count
6
形式电荷Formal Charge
0
复杂度Complexity
59.100
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
1
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 H2624300 |
分析证书 | P169115 |
| H2624321 |
分析证书 | P169115 |
| H2624322 |
分析证书 | P169115 |
| H2624323 |
分析证书 | P169115 |
| L2215058 |
分析证书 | P169115 |
| L2215305 |
分析证书 | P169115 |
| L2215399 |
分析证书 | P169115 |
| F2512066 |
分析证书 | P169115 |
| L2109339 |
分析证书 | P169115 |
| A2510032 |
分析证书 | P169115 |
| B2508111 |
分析证书 | P169115 |
| H2407066 |
分析证书 | P169115 |
| L2215045 |
分析证书 | P169115 |
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此产品的引用文献
引用文献
| 1. Xia Zunbin, Zuo Wei, Li Haiying, Qiu Liewei, Mu Ruihua, Wang Qian, Liu Hongchen, Wang Huixin, Hui Yuchen. (2023) Wearable cellulose textile matrix self-powered biosensor sensing lactate in human sweat. JOURNAL OF APPLIED ELECTROCHEMISTRY, [10.1007/s10800-023-02010-x] |
| 2. Zhang Wenqin, Cai Xiaozhen, Zhang Xinyi, Zou Shiqi, Zhu Danhong, Zhang Qiulong, Chen Jianmin. (2023) AgNPs-Modified Polylactic Acid Microneedles: Preparation and In Vivo/In Vitro Antimicrobial Studies. PHARMACEUTICAL RESEARCH, [PMID:37985572] [10.1007/s11095-023-03634-6] |
| 3. Qianqian Chen, Aochen Wang, Dan Yang, Xuelian Wei, Li'ang Zhang, Zhiyi Wu, Longfei Wang, Yong Qin. (2023) Largely Improving the Output Performance of Stretchable Triboelectric Nanogenerators via Thermo-Compressive Technology. Small, [PMID:37940630] [10.1002/smll.202307070] |
| 4. Chen Na, Du Na, Shen Ruichen, He Tianpei, Xi Jing, Tan Jie, Bian Guangkai, Yang Yanbing, Liu Tiangang, Tan Weihong, Yu Lilei, Yuan Quan. (2023) Redox signaling-driven modulation of microbial biosynthesis and biocatalysis. Nature Communications, 14 (1): (1-13). [PMID:37884498] [10.1038/s41467-023-42561-3] |
| 5. Xiangnan Wang, Hongli Zhang, Jiahe Li, Gang Zou. (2023) Monitoring of Sweat pH and Dual-Mode Anti-Counterfeiting from Metal-Organic Framework-Based Multifunctional Gel. CHINESE JOURNAL OF CHEMISTRY, 42 (5): (491-498). [10.1002/cjoc.202300416] |
| 6. Haiwei Ren, Siqi Li, Ming Gao, Xueye Xing, Yaqin Tian, Zhe Ling, Weixia Yang, Lichao Pan, Wenguang Fan, Yi Zheng. (2023) Preparation and Characterization of Microcrystalline Cellulose/Polylactic Acid Biocomposite Films and Its Application in Lanzhou Lily (Lilium davidii var. unicolor) Bulbs Preservation. Sustainability, 15 (18): (13770). [10.3390/su151813770] |
| 7. Junyan Wang, Liang Liang, Wei Shang, Noor Huda Ismail, Raja Azman Awang. (2023) Effects of hydroxylapatite microtubules/polylactic acid guided tissue regeneration membrane on periodontal bone. PROCESS BIOCHEMISTRY, [10.1016/j.procbio.2023.09.007] |
| 8. Yingying Zhang, Xiaoci Cui, Xin Wang, Xiuyuan Feng, Yankang Deng, Weixia Cheng, Ranhua Xiong, Chaobo Huang. (2023) Xylan derived carbon dots composite ZIF-8 and its immobilized carbon fibers membrane for fluorescence selective detection Cu2+ in real samples. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2023.145804] |
| 9. Xiaoyan Tang, Xun Guo, Yongchao Duo, Xiaoming Qian. (2023) Preparation and Characterization of a One-Step Electrospun Poly(Lactic Acid)/Wormwood Oil Antibacterial Nanofiber Membrane. Polymers, 15 (17): (3585). [PMID:37688211] [10.3390/polym15173585] |
| 10. Yufang Li, Xiaozhao Tang, Zushun Yang, Jinze He, Ni Ma, Aixiang Huang, Yanan Shi. (2023) BCp12/PLA combination: A novel antibacterial agent targeting Mur family, DNA gyrase and DHFR. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, [PMID:37678070] [10.1016/j.ijfoodmicro.2023.110370] |
| 11. Cunmin Wang, Xinyi Song, Tian Li, Xuanjin Zhu, Shugui Yang, Jintuo Zhu, Xinjian He, Jiefeng Gao, Huan Xu. (2023) Biodegradable Electroactive Nanofibrous Air Filters for Long-Term Respiratory Healthcare and Self-Powered Monitoring. ACS Applied Materials & Interfaces, [PMID:37490285] [10.1021/acsami.3c08490] |
| 12. Yihang Zhang, Jing Guo, Fucheng Guan, Xuecui Song, Qiang Yang, Xinbin Ji, Zheng Li, Jing Tao. (2023) Guar gum-based multilayer fiber membranes inspired by plant transpiration for enhancing the functionality of dry facial masks. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:37487991] [10.1016/j.ijbiomac.2023.125965] |
| 13. Weitao Wang, Ben Niu, Ruiling Liu, Hangjun Chen, Xiangjun Fang, Weijie Wu, Guannan Wang, Haiyan Gao, Honglei Mu. (2023) Development of bio-based PLA/cellulose antibacterial packaging and its application for the storage of shiitake mushroom. FOOD CHEMISTRY, [PMID:37487388] [10.1016/j.foodchem.2023.136905] |
| 14. Shoujie Guan, Jiaxuan Li, Yuyang Wang, Yang Yang, Xun Zhu, Dingding Ye, Rong Chen, Qiang Liao. (2023) Multifunctional MOF-derived Au, Co-doped porous Carbon Electrode for Wearable Sweat Energy Harvesting-storage Hybrid System. ADVANCED MATERIALS, [PMID:37318943] [10.1002/adma.202304465] |
| 15. Wan Peng, Cheng Liu, Youjin Lai, Yanting Wang, Pingsheng Liu, Jian Shen. (2023) An Adhesive/Anti-Adhesive Janus Tissue Patch for Efficient Closure of Bleeding Tissue with Inhibited Postoperative Adhesion. Advanced Science, [PMID:37173819] [10.1002/advs.202301427] |
| 16. Xiuhua Sun, Shanshan Pan, Zhiren Guo, Yingxin Cui, Liang Ma, Xiaosong Yu, Taijiang Gui, Shougang Chen, Yan Liu, Changlu Gao. (2023) Synergy effect of bactericidal and antifouling with structure reversion and hydrolysis of cationic amphiphilic copolymer PHMA-b-PCBMAE to zwitterionic copolymer. PROGRESS IN ORGANIC COATINGS, [10.1016/j.porgcoat.2023.107508] |
| 17. Lin Hongyang, Yang Yang, Li Yongxia, Feng Xuedong, Li Qiuhong, Niu Xiaoyin, Ma Yanfei, Liu Aijv. (2023) Bioenhanced degradation of toluene by layer-by-layer self-assembled silica-based bio-microcapsules. Frontiers in Microbiology, [PMID:36891398] [10.3389/fmicb.2023.1122966] |
| 18. Guofeng Zhong, Mengyu Qiu, Junbo Zhang, Fuchen Jiang, Xuan Yue, Chi Huang, Shiyi Zhao, Rui Zeng, Chen Zhang, Yan Qu. (2023) Fabrication and characterization of PVA@PLA electrospinning nanofibers embedded with Bletilla striata polysaccharide and Rosmarinic acid to promote wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:36806778] [10.1016/j.ijbiomac.2023.123693] |
| 19. Hui Liang, Xihua Du, Jing Li, Limei Sun, Ming Song, Wenjiang Li. (2023) Manipulating active sites on carbon nanotube materials for highly efficient hydrogen storage. APPLIED SURFACE SCIENCE, [10.1016/j.apsusc.2023.156740] |
| 20. Jiaxin Liu, Canying Li, Chenyang Zhang, Rui Huang, Linhong Qu, Yonghong Ge. (2023) 2-hydroxy-3-phenylpropanoic acid suppressed the growth of Alternaria alternata through damaging cell membrane integrity and modulating reactive oxygen species metabolism. Fungal Biology, [PMID:36906385] [10.1016/j.funbio.2023.02.001] |
| 21. Fenghua Shen, Hanmin Peng, Song Pan, Pancheng Zhu. (2023) Phased array ultrasound enhanced delivery of nano drugs for tendon adhesion treatment. APPLIED ACOUSTICS, [10.1016/j.apacoust.2023.109231] |
| 22. Yining Ding, Lei Xu, Shengnan Chen, Youfu Zhu, Yuehua Sun, Liqiang Ding, Bingyu Yan, Seeram Ramakrishna, Jun Zhang, Yun-Ze Long. (2023) Mxene composite fibers with advanced thermal management for inhibiting tumor recurrence and accelerating wound healing. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2023.141529] |
| 23. Haiwei Ren, Zhihang Xu, Ming Gao, Xueye Xing, Zhe Ling, Lichao Pan, Yaqin Tian, Yi Zheng, Wenguang Fan, Weixia Yang. (2022) Preparation of microcrystalline cellulose from agricultural residues and their application as polylactic acid/microcrystalline cellulose composite films for the preservation of Lanzhou lily. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:36563803] [10.1016/j.ijbiomac.2022.12.198] |
| 24. Zihan Lang, Lidong Xue. (2022) Can Polylactic Acid (PLA) Act as an Important Vector for Triclosan?. Sustainability, 14 (19): (12872). [10.3390/su141912872] |
| 25. Ping Chen, Chao Xu, Ping Wu, Kun Liu, Feixiang Chen, Yun Chen, Honglian Dai, Zhiqiang Luo. (2022) Wirelessly Powered Electrical-Stimulation Based on Biodegradable 3D Piezoelectric Scaffolds Promotes the Spinal Cord Injury Repair. ACS Nano, [PMID:36174221] [10.1021/acsnano.2c05818] |
| 26. Minying Huang, Yan Zhu, Yanhong Chen, Yuting Liang. (2022) Microplastics in soil ecosystems: soil fauna responses to field applications of conventional and biodegradable microplastics. JOURNAL OF HAZARDOUS MATERIALS, [PMID:36099741] [10.1016/j.jhazmat.2022.129943] |
| 27. Zhufang Wang, Yinglong Su, Jundong Zhu, Dong Wu, Bing Xie. (2022) Size-dependent effects of microplastics on antibiotic resistance genes fate in wastewater treatment systems: The role of changed surface property and microbial assemblages in a continuous exposure mode. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:36037899] [10.1016/j.scitotenv.2022.158264] |
| 28. Yucui Huangfu, Zhipeng Xie, Tianxiang Wang, Jie Ding, Zhaoyang Chen, Yueming Zhai. (2022) Elucidating the Origin of Enhanced Photocatalytic Hydrogen Production on Tuned Cu7S4/CdS Heterostructures. Chemistry-An Asian Journal, 17 (20): (e202200645). [PMID:35982529] [10.1002/asia.202200645] |
| 29. Hanhao Huang, Yulian Shang, Haofei Li, Qi Feng, Yang Liu, Junlin Chen, Hua Dong. (2022) Co-transplantation of Islets-Laden Microgels and Biodegradable O2-Generating Microspheres for Diabetes Treatment. ACS Applied Materials & Interfaces, [PMID:35980755] [10.1021/acsami.2c07215] |
| 30. Xiaoping Yue, Feiyang Xu, Linrong Zhang, Guozhang Ren, Huixiang Sheng, Jin Wang, Kaili Wang, Liuyingzi Yu, Junjie Wang, Gongqiang Li, Gang Lu, Hai-Dong Yu. (2022) Simple, Skin-Attachable, and Multifunctional Colorimetric Sweat Sensor. ACS Sensors, [PMID:35903889] [10.1021/acssensors.2c00581] |
| 31. Hui Liang, Benliang Cao, Junxiang Zhu, Xinhui Shen, Mengya Zhu, Baozhang Geng, Pengfei Zhang, Shule Zhu, Feiyang Yu, Rou Zhang, Hao Tang, Qiaoqiao Yuan, Jing Li, Wenjiang Li, Yan Chen. (2022) Intercalation optimized hexagonal boron nitride nanosheets for high efficiency hydrogen storage. APPLIED SURFACE SCIENCE, [10.1016/j.apsusc.2022.154118] |
| 32. Wenguang Fan, Baoyu Li, Nana Du, Tian Hui, Yingying Cao, Xin Li, Haiwei Ren. (2022) Energy metabolism as the target of 3-phenyllactic acid against Rhizopus oryzae. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, [PMID:35287031] [10.1016/j.ijfoodmicro.2022.109606] |
| 33. Chonghui Zhu, Hua Xue, Hongran Zhao, Teng Fei, Sen Liu, Qidai Chen, Bingrong Gao, Tong Zhang. (2022) A dual-functional polyaniline film-based flexible electrochemical sensor for the detection of pH and lactate in sweat of the human body. TALANTA, [PMID:35151973] [10.1016/j.talanta.2022.123289] |
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