计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
PARP/PI3K-IN-1 (compound 15) is a potent PARP/PI3K inhibitor with pIC 50 values of 8.22, 8.44, 8.25, 6.54, 8.13, 6.08 for PARP-1, PARP-2, PI3Kα , PI3Kβ , PI3Kδ , and PI3Kγ , respectively. PARP/PI3K-IN-1 is a highly effective anticancer compound targeted against a wide range of oncologic diseases
In Vitro
PARP/PI3K-IN-1 (compound 15; 1 μM; 72 hours) leads to a significant increase in cell apoptosis. PARP/PI3K-IN-1 (1 μM; 72 hours) reduces the autophosphorylation levels of AKT and S6 while increases the autophosphorylation level of ERK after treating cells, indicating that it can inhibit the PI3K pathway and activate the ERK pathway. PARP/PI3K-IN-1 (1 μM) displays a strong capability to downregulate the expression of BRCA1/2 at the mRNA level in MDA-MB-468 cancer cells. PARP/PI3K-IN-1 not only shows significant inhibitory activity against BRCA-deficient cells HCC1937 and HCT116, but also displays potent anti-proliferative activity against BRCA-proficient cells MDA-MB-231 and MDA-MB-468. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: MDA-MB-468 cancer cells Concentration: 1 μM Incubation Time: 72 hours Result: Led to a significant increase in cell apoptosis. Western Blot AnalysisCell Line: MDA-MB-468 cancer cells Concentration: 1 μM Incubation Time: 72 hours Result: Reduced the autophosphorylation levels of AKT and S6 while increased the autophosphorylation level of ERK after treating cells.
In Vivo
PARP/PI3K-IN-1 (i.p.; 50 mg/kg; twice daily (BID) for 34 consecutive days) significantly suppresses the tumor growth . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Six-week-old male BALB/c nude mice with MDA-MB-468 cells Dosage: 50 mg/kg Administration: i.p.; twice daily (BID) for 34 consecutive days Result: Significantly suppressed the tumor growth.
Form:Solid
IC50& Target:PARP-1 8.22 (pIC 50 ) PARP-2 8.44 (pIC 50 ) PI3Kα 8.25 (pIC 50 ) PI3Kβ 6.54 (pIC 50 ) PI3Kδ 8.13 (pIC 50 ) PI3Kγ 6.08 (pIC 50 )
规格
规格或纯度
≥98%
英文名称
PARP/PI3K-IN-1
生化机理
PARP/PI3K-IN-1 （化合物 15）是一种强效 PARP/PI3K 抑制剂，对 PARP-1、PARP-2、PI3Kα、PI3Kβ、PI3Kδ 和 PI3Kγ 的 pIC 50 值分别为 8.22、8.44、8.25、6.54、8.13 和 6.08。PARP/PI3K-IN-1是一种高效的抗癌化合物，其靶标是
储存条件
-20°C储存
运输条件
超低温运输
作用类型
激活剂
纯度
≥98%
名称和识别符
分子类型
小分子
IUPAC Name
4-[[3-[2-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-4-morpholin-4-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carbonyl]-4-fluorophenyl]methyl]-4H-phthalazin-1-one
INCHI
1S/C33H28F4N8O3/c34-25-6-5-18(14-26-19-3-1-2-4-20(19)31(46)43-42-26)13-22(25)32(47)45-8-7-21-27(17-45)40-29(41-30(21)44-9-11-48-12-10-44)23-16-39-28(38)15-24(23)33(35,36)37/h1-6,13,15-16,26H,7-12,14,17H2,(H2,38,39)
InChi Key
ZEXPYRCUAZYANY-UHFFFAOYSA-N
Smiles
C1CN(CC2=C1C(=NC(=N2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4)C(=O)C5=C(C=CC(=C5)CC6C7=CC=CC=C7C(=O)N=N6)F
PubChem CID
分子量
660.62
技术文档
高级数据
三维结构
交互式化学结构模型
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥98%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于?20 °C条件下保存。需冷冻保存以维持规定的有效期。
本产品如何运输？
本产品采用保温箱配冰袋运输。收货后请立即拆包，并按上述储存条件保存。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 2337386-47-5，分子式为 C33H28F4N8O3，分子量为 660.62 g/mol。InChIKey ZEXPYRCUAZYANY-UHFFFAOYSA-N。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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