PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC 50 of 2.5 nM
In Vitro
PERK-IN-6 (Compound 5) inhibits thapsigargin induced PERK autophosphorylation with an IC 50 of 0.1-0.3 μΜ in A549 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
The rat blood clearance of PERK-IN-6 (Compound 5) is 10.5 mL/min/kg after i.v infusion in SD rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only.