计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer.
In Vitro
QN523 (72 h) has cytotoxicity with IC 50 values ranging from 0.1 to 5.7 μM across 12 cell lines. QN523 (0.1 and 0.5 μM; 24 and 48 h; MIA PaCa-2 cells) arrests cell cycle at S phase and delays for pancreatic cancer cells to enter the G2-M phase. QN523 induces apoptosis and autophagy of MIA PaCa-2 Cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cycle AnalysisCell Line: MIA PaCa-2 cells Concentration: 0.1 and 0.5 μM Incubation Time: 24 and 48 hours Result: Delayed for pancreatic cancer cells to enter the G2-M phase because of accumulation of cells in the S phase. Apoptosis AnalysisCell Line: MIA PaCa-2 cells Concentration: 0.1 and 0.5 μM Incubation Time: 24 and 48 hours Result: Increased the number of apoptotic cell in time- and dose-dependent manner.
In Vivo
QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: NOD/SCID mice of pancreatic cancer xenografts (6 weeks of age) Dosage: 10 and 20 mg/kg Administration: Intraperitoneal administration; 1-9 days (10 mg/kg), 10-44 days (20 mg/kg) Result: Delayed growth of the tumors, and no systemic toxicity.
Form:Solid
规格
规格或纯度
≥99%
英文名称
QN523
生化机理
QN523 是一种新型支架，具有类似制剂的特性，在 12 种癌症细胞系中显示出强大的体外细胞毒性。QN523 可诱导细胞凋亡和自噬。QN523 可用于癌症研究。
储存条件
避光,-80℃储存
运输条件
特低温运输
纯度
≥99%
名称和识别符
分子类型
小分子
Smiles
O=C(C1=NC=CN=C1)NC2=CC=CC3=CC=CN=C32
分子量
250.26
技术文档
高级数据
化学和物理性质
溶解性
DMSO : ≥ 16.67 mg/mL (66.61 mM)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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