The U1 small molecule nuclear ribonucleoprotein (U1 snRNP) antigen is an RNP/Sm multi enzyme complex composed of three U1 specific ribonucleoproteins (RNP-A, RNP-C, RNP-68K) and different Sm nucleoproteins (B/B ', D, E, F, G). RNP/Sm complex is an extractable nuclear antigen (ENA) that targets self reactive B and T cells in various rheumatic diseases. Anti RNP antibodies bind to peptides specific for U1 snRNA (RNP-A, RNP-C, RNP-68K), while anti Sm antibodies can bind to peptides specific for U1, U2, U5, and U4/6 snRNA. High titer anti-U1 snRNP autoantibodies are one of the important criteria for diagnosing mixed connective tissue diseases (MCTD, Sharpe syndrome), with a positivity rate of up to 95% -100%, and antibody titers are correlated with disease activity. This antibody can also be detected in 30% -40% of systemic lupus erythematosus (SLE) patients, but almost always accompanied by anti Sm antibodies. Anti-U1-snRNP autoantibodies can also be found in the serum of patients with other rheumatic and immune diseases, including dermatomyositis (10% -20%), unclassified connective tissue disease (20%), Sjogren's syndrome (20%), scleroderma (7%), and overlap syndrome (27%).
Store at -80℃ for 6 years. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
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Native Bovine RNP/Sm Protein (R572725) - SDS-PAGE 2 μg/lane of Native Bovine RNP/Sm Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 29 - 35 kDa (RNP subunits) & 7 - 15 kDa (Sm subunits).
ZJ25F0117286
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