计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥95% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
RMC-6272 (RM-006) is a bi-steric mTORC1 -selective inhibitor. RMC-6272 exhibits potent and selective (> 10-fold) inhibition of mTORC1 over mTORC2. RMC-6272 shows improved inhibition of mTORC1 in comparison to Rapamycin, and induces more cell death in TSC2 tumors.
In Vitro
RMC-6272 shows more effective growth inhibition in multiple TSC1 or TSC2 mutant tumor cell lines compared to Rapamycin. RMC-6272 causes a more profound growth inhibition in the TSC1 or TSC2 mutant cells than the wild type cells. RMC-6272 at ~1 nM shows near complete inhibition of p4E-BP1 T37/46 , while inhibition of pS6 S240/244 levels is similar for Rapamycin and RM compounds. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
RMC-6272 markedly reduces kidney tumor burden in Tsc2 +/- A/J mice after four weeks of treatment. Tumor regrowth is assessed two months after treatment cessation, tumor burden is significantly reduced in the RMC-6272 group as compared to the Rapamycin and MLN0128 groups . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
规格
规格或纯度
≥95%
英文名称
RMC-6272
生化机理
RMC-6272 (RM-006) 是一种双甾体 mTORC1 选择性抑制剂。RMC-6272 对 mTORC1 的抑制作用强于 mTORC2，且具有选择性（> 10 倍）。与雷帕霉素相比，RMC-6272 能更好地抑制 mTORC1，并能诱导更多的 TSC 细胞死亡。
储存条件
-20°C储存
运输条件
超低温运输
纯度
≥95%
名称和识别符
分子类型
小分子
Smiles
O=C(C1=C(C(F)=C(C=C1)S(CCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(O[C@H]2[C@@H](C[C@@H](CC2)C[C@H]([C@@]3([H])OC([C@@]4([H])N(CCCC4)C(C([C@@]5(O[C@](CC[C@H]5C)([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@@H]([C@@H](/C(C)=C/[C@H]([C@@H](C3)O)C)O)OC)=O)C)C)OC)O)=O
分子量
1850.22
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 25 mg/mL (13.51 mM; ultrasonic and warming and heat to 60°C)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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