计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Rohinitib is a potent and specific eIF4A inhibitor. Rohinitib induces cell apoptosis of acute myeloid leukemia (AML) cell lines and reduces the leukemia burden of AML xenograft model. Rohinitib can be used for the research of AML.
In Vitro
Rohinitib (6.25-50 nM; 72 h) induces cell apoptosis of AML cell lines and FLT3 -ITD-positive AML cell lines. Primary AML cells is more sensitive to Rohinitib (25 nM; 72 h) than normal bone marrow (BM) and FLT3 -ITD-positive cells is more sensitive to Rohinitib than FLT3 wild-type AML cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: AML cell lines Concentration: 6.25, 12.5, 25 and 50 nM Incubation Time: 72 h Result: Dose-dependently induced apoptosis of MOLM-13, MOLM-14, MV4;11, OCI-AML3, THP-1, HL-60, Kasumi-1 and NB4 cell lines. And significantly induced cell apoptosis of FLT3 -ITD, FLT3 -ITD-expressing murine Ba/F3 and human OCI-AML3 cells.
In Vivo
Rohinitib (0.75 and 1.0 mg/kg; s.c. once daily for 5 consecutive days until mice get moribund) shows anti-AML effects in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female NSG mice with AML xenografts generated by intravenous injections of MOLM-13 cells Dosage: 0.75 and 1.0 mg/kg Administration: Subcutaneous injection; 0.75 and 1.0 mg/kg once daily 5 days a week until mice get moribund Result: Significantly reduced the leukemia burden, circulating and BM leukemic human CD45 + cells. Dose-dependently prolonged the survival rate of mice.
Form:Solid
规格
别名
罗欣替尼
规格或纯度
≥99%
英文名称
Rohinitib
生化机理
罗希尼替（Rohinitib）是一种强效特异性 eIF4A 抑制剂。罗希尼替（Rohinitib）能诱导急性髓性白血病（AML）细胞株的细胞凋亡，并能减轻AML异种移植模型的白血病负担。罗希尼替（Rohinitib）可用于急性髓性白血病的研究。
储存条件
-20°C储存
运输条件
超低温运输
纯度
≥99%
名称和识别符
分子类型
小分子
Smiles
COC1=CC=C([C@@]23OC4=CC(OC)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(N(OC)C)=O)O)C=C1
分子量
521.56
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 200 mg/mL (383.46 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）