计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA 2 ) , with an EC 50 value of 25 nM for murine LPA 2 subtype
In Vitro
Radioprotectin-1 is a potent agonist of LPA 2 with an EC 50 of 5 pM and functions as a full agonist at the human ortholog of LPA 2. Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA 2 either endogenously or after transfection. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MEF cells , IEC-6 cells Concentration: 0 μM, 0.1 μM, 0.3 μM, 1.0 μM,3 μM Incubation Time: 15 minutes Result: Protected cells from apoptosis by γ-irradiation- and the radiomimetic chemotherapeutic\nAdiamycin.
In Vivo
Radioprotectin-1 is a high-potency specific agonist of the murine LPA 2 GPCR . Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) . Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA 2 GPCR in Lgr5 + stem cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI) Dosage: 0.1 mg/kg, 0.3 mg/kg Administration: Subcutaneous injection; every 12 hours; for 3 days Result: Decreased mortality of C57BL/6 mice in models of the HE-ARS and the GI-ARS.
Form:Solid
IC50& Target:EC50: 25 nM (murine LPA 2 subtype)
规格
别名
放射保护素-1
规格或纯度
≥99%
英文名称
Radioprotectin-1
生化机理
辐射保护蛋白-1 是溶血磷脂酸受体 2（LPA 2）的一种强效特异性非脂类激动剂，对小鼠 LPA 2 亚型的 EC 50 值为 25 nM。
储存条件
-20°C储存
运输条件
超低温运输
纯度
≥99%
名称和识别符
EC号
836-431-3
分子类型
小分子
Isomeric SMILES
C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCNS(=O)(=O)C4=C(C=C(C=C4)Cl)C(=O)O
PubChem CID
分子量
486.92
技术文档
高级数据
关联靶点（人）
LPAR1
Tchem
Lysophosphatidic acid receptor Edg-2
(779 活性数据)
LPAR2
Tchem
Lysophosphatidic acid receptor Edg-4
(418 活性数据)
LPAR3
Tchem
Lysophosphatidic acid receptor Edg-7
(471 活性数据)
LPAR4
Tchem
Lysophosphatidic acid receptor 4
(71 活性数据)
关联靶点（其它种属）
CHO (4503 活性数据)
MEF (1005 活性数据)
B103 cell line (42 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
DMSO : 125 mg/mL (256.72 mM; Need ultrasonic) H2O : <0.1 mg/mL (insoluble)
分子量
486.900 g/mol
XLogP3
3.700
氢键供体数Hydrogen Bond Donor Count
2
氢键受体数Hydrogen Bond Acceptor Count
7
可旋转键计数Rotatable Bond Count
8
精确质量Exact Mass
486.065 Da
单同位素质量Monoisotopic Mass
486.065 Da
拓扑极表面积Topological Polar Surface Area
129.000 Ų
重原子数Heavy Atom Count
33
形式电荷Formal Charge
0
复杂度Complexity
845.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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