ActiBioPure™,Fc标签,His标签,无动物源,无叠氮钠,无载体,生物活性 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Purity
≥95% SDS-PAGE.
Endotoxin level
<0.1 EU/µg
Background:
Butyrophilin 3A1 (also called BTN3A1) is a 57 kDa type I transmembrane glycoprotein member of the Ig superfamily. It is expressed on a wide variety of immune cells. Similar to BTN3A2 and BTN3A3, BTN3A1 (484 amino acids) is composed of an extracellular N-terminal IgV and a membrane-proximal IgC domain followed by a transmembrane domain and a cytoplasmic tail. These Ig domains are also found in B7 family co-stimulatory molecules, suggesting structural and functional similarities between the two protein families. The intracellular portion of BTN3A1 contains a B30.2 domain. Although the B30.2 domain of BTN1A1 binds to xanthine oxidoreductase (XOR) and is conserved among BTN1A1 orthologs, this interaction with XOR is not shared by BTN3A1. The B30.2 domain of butyrophilins also functions as a sensor for detecting changes in intracellular phopho-antigen (pAg) concentrations produced during tumorigenesis and microbial infections. The specific binding of pAg by the B30.2 domain of BTN3A1 induces a conformational change in its ECD, leading to the activation of V gamma 9Vδ2 T cells. Thus, BTN3A1 acts as a critical protein for the activation of V gamma 9Vδ2 T cells following detection of distressed cells. The anti-tumor responses of V gamma 9Vδ2 T cells may be enhanced with agonistic anti-BTNA3 antibodies. No BTN3A1 homolog has yet been identified in rodents. However, Human BTN3A1 shares 92.4% and 91.6% sequence identity with baboon and rhesus monkey BTN3A1 respectively.
Recombinant Human CD277/BTN3A1 Protein (rp143418) - SDS-PAGE
3 μg/lane of Recombinant Human CD277/BTN3A1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 58 kDa under reducing condition and 116 kDa under non-reducing condition.
Recombinant Human CD277/BTN3A1 Protein (rp143418) - Protein Bioactivity
Measured by its ability to inhibit Anti-CD3-induced proliferation of Jurkat cells. The ED₅₀ for this effect is 55.72 ng/mL.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ25F0116995 |
分析证书 | rp143418 |
| ZJ25F0116996 |
分析证书 | rp143418 |
| ZJ25F0116997 |
分析证书 | rp143418 |
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