Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
规格
产品名称
Recombinant Human CD46 Protein
别名
膜辅蛋白(MCP)重组蛋白 | 重组人 CD46 蛋白
英文别名
AHUS2 | Antigen defined by monoclonal antibody TRA 2 10 | Antigen identified by monoclonal antibody TRA 2 10 | CD46 | CD46 antigen | CD46 antigen complement regulatory protein | CD46 molecule | CD46 molecule complement regulatory protein | Complement memb
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
图片
Recombinant Human CD46 Protein (rp144024) - Protein Bioactivity Immobilized Recombinant Human CD46 Protein (rp144024) at 1.0 μg/mL can bind CD46 antibody with a linear range of 0.2 - 3.8 ng/mL.
Recombinant Human CD46 Protein (rp144024) - SDS-PAGE 3 μg/lane of Recombinant Human CD46 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 55.0 kDa.