May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
规格
产品名称
Recombinant Human DR6/TNFRSF21 Protein
别名
重组人DR6/TNFRSF21蛋白 | 重组人肿瘤坏死因子受体超家族成员21蛋白
英文别名
Death receptor 6 | BM-018 | CD358 antigen | CD358 | Death receptor 6 | DR6 | DR6TNFR-related death receptor 6 | MGC31965 | TNFRSF21 | tumor necrosis factor receptor superfamily member 21 | tumor necrosis factor receptor superfamily, member 21
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。复溶后建议分装。避免冷冻/解冻循环。
图片
Recombinant Human DR6/TNFRSF21 Protein (rp145276) - SDS-PAGE 2 μg/lane of Recombinant Human DR6/TNFRSF21 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 80 - 95 kDa under reducing conditions and 180 - 240 kDa under non-reducing conditions.
ZJ25F0724647
危险品化学品经营许可证（带存储）