Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Ephrin-A1 Protein (rp145628) at 2.0 μg/mL can bind Human EphA1 with the ED50 is 21.1 ng/mL.
Function Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cones.
规格
产品名称
Recombinant Human Ephrin-A1 Protein
别名
肝配蛋白A1(EFNA1)重组蛋白
英文别名
EPH-related receptor tyrosine kinase ligand 1 | Immediate early response protein B61 | LERK-1 | TNF alpha-induced protein 4 | Tumor necrosis factor alpha-induced protein 4 | ECKLG | EFL 1 | EFL1 | EFNA 1 | Efna1 | EFNA1_HUMAN | EPH related receptor tyrosi
规格或纯度
无动物源,无载体,生物活性,ActiBioPure™,His标签,≥95%(SDS-PAGE)
生物活性
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Ephrin-A1 Protein (rp145628) at 2.0 μg/mL can bind Human EphA1 with the ED50 is 21.1 ng/mL.
25 kDa, under reducing conditions; 25 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
图片
Recombinant Human Ephrin-A1 Protein (rp145628) - Protein Bioactivity Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Ephrin-A1 Protein (rp145628) at 2.0 μg/mL can bind Human EphA1 with the ED50 is 21.1 ng/mL.
Recombinant Human Ephrin-A1 Protein (rp145628) - SDS-PAGE 3 μg/lane of Recombinant Human Ephrin-A1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 25 kDa.
ZJ25F0116959
危险品化学品经营许可证（带存储）