Purity ≥95% (SDS-PAGE) Endotoxin level <0.1 EU/μg Function Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintainance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Seems to be involved in palatogenesis.
规格
产品名称
Recombinant Human PDGFC Protein
别名
血小板衍生生长因子C(PDGFC)重组蛋白 | 重组人PDGFC蛋白
英文别名
Fallotein | HSCDGF | PDGF-C | PDGFC | PDGFC latent form | PDGFC receptor-binding form | PDGFC_HUMAN | Platelet derived growth factor C | Platelet-derived growth factor C, receptor-binding form | SCDGF | Secretory growth factor like protein | Secretory gro
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
图片
Recombinant Human PDGFC Protein (rp149966) - Protein Bioactivity Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED₅₀ for this effect is 1.53 μg/mL.
Recombinant Human PDGFC Protein (rp149966) - SDS-PAGE 3 μg/lane of Recombinant Human PDGFC Protein was resolved with SDS-PAGE under reducing (R) condition and visualized by Coomassie® Blue staining, showing the bands at 45 & 90 kDa.