Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
规格
产品名称
Recombinant Human Semaphorin 5A Protein
别名
重组人Semaphorin 5A蛋白 | 重组人信号素5A蛋白
英文别名
Sema F | Semaphorin-F | FLJ12815 | sema domain, seven thrombospondin repeats (type 1 and type 1-like) | Sema F | SEMA5A | SEMAF | Semaphorin 5A | semaphorin F | semaphorin-5A | Semaphorin-F | semF | transmembrane domain (TM) and short cytoplasmic domain,
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。复溶后建议分装。避免冷冻/解冻循环。
图片
Recombinant Human Semaphorin 5A Protein (rp151382) - SDS-PAGE 2 μg/lane of Recombinant Human Semaphorin 5A Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 108 kDa under reducing conditions and 240 kDa under non-reducing conditions.
ZJ25F0522103
危险品化学品经营许可证（带存储）