Immobilized Recombinant Human IGSF4A/SynCAM1 Protein (rp152013) can bind Recombinant Human CRTAM Protein with a line arrange of 62.5 - 500.0 ng/mL and the EC50 for this effect is 445.1 ng/mL.
Function Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Immobilized Recombinant Human IGSF4A/SynCAM1 Protein (rp152013) can bind Recombinant Human CRTAM Protein with a line arrange of 62.5 - 500.0 ng/mL and the EC50 for this effect is 445.1 ng/mL.
50 - 80 kDa, under reducing conditions; 50 - 80 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
图片
Recombinant Human IGSF4A/SynCAM1 Protein (rp152013) - Protein Bioactivity Immobilized Recombinant Human IGSF4A/SynCAM1 Protein (rp152013) can bind Recombinant Human CRTAM Protein with a line arrange of 62.5 - 500.0 ng/mL and the EC50 for this effect is 445.1 ng/mL.
Recombinant Human IGSF4A/SynCAM1 Protein (rp152013) - SDS-PAGE 3 μg/lane of Recombinant Human IGSF4A/SynCAM1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 50 - 80 kDa.