| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| rp152658-10μg |
10μg |
现货  |
| |
| rp152658-50μg |
50μg |
现货 |
| |
| rp152658-100μg |
100μg |
现货 |
| |
| rp152658-1mg |
1mg |
期货 |
|
| 产品名称 | Recombinant Human TREM-1 Protein |
|---|---|
| 别名 | 重组人TREM-1蛋白 | 重组人髓细胞触发受体1蛋白 |
| 英文别名 | TREM-1 | Triggering receptor expressed on monocytes 1 | Triggering Receptor Expressed on Myeloid Cells 1 | CD354 antigen | CD354 | TREM1 | TREM-1 | Triggering receptor expressed on monocytes 1 | triggering-receptor TREM1 |
| 规格或纯度 | ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE) |
| 产品介绍 |
Purity |
| 生物活性 | Measured by its ability to block anti-TREM-1-induced TNF-alpha secretion by human peripheral blood mononuclear cells (PBMC). At 1 µg/mL, Recombinant Human TREM‑1 Fc Chimera is able to block > 70% of Goat Anti-Human TREM-1 (20 µg/mL, 200 µL/well) induced TNF-alpha released from 1 x 10^5 cells. |
| 内毒素水平 | <0.1 EU/μg |
| 表达系统 | HEK293 |
| 种属 | 人(Human) |
| 氨基酸 | 21-200 aa |
| 序列 | ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH |
| 蛋白标签 | C-hFc & His |
| 无载体 | Yes |
| 无动物源 | Yes |
| Accession # | Q9NP99 |
| 来源 | 重组表达 |
| 预测分子量 | 48 kDa |
| SDS-PAGE | 55 - 70 kDa, under reducing conditions; 120 -180 kDa, under non-reducing conditions. |
Recombinant Human TREM-1 Protein (rp152658) - SDS-PAGE
3 μg/lane of Recombinant Human TREM-1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 55 - 70 kDa under reducing conditions and 120 -180 kDa under non-reducing conditions.
| 物理形态 | 冻干(Lyophilized) |
|---|---|
| 储存缓冲液 | Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4. |
| 复溶 | Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml. |
| 储存温度 | -20°C储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。 |
| 分子类型 | 蛋白质 |
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F1215039 |
分析证书 | 24-12-11 | rp152658 |
| ZJ24F1215038 |
分析证书 | 24-12-11 | rp152658 |
| ZJ24F1215037 |
分析证书 | 24-12-11 | rp152658 |
| 1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K et al.. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat Genet, 36 (1): (40-5). [PMID:14702039] [10.1021/op500134e] |
| 2. Agnihotri G, Ukani R, Malladi SS, Warshakoon HJ, Balakrishna R, Wang X, David SA.. (2011) Structure-activity relationships in nucleotide oligomerization domain 1 (Nod1) agonistic γ-glutamyldiaminopimelic acid derivatives.. J Med Chem, 54 (5): (1490-1510). [PMID:21299227] [10.1021/jm101535e] |
| 3. Bouchon, A A, Dietrich, J J and Colonna, M M.. (2000) Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10799849] |
| 4. Bouchon, A A, Facchetti, F F, Weigand, M A MA and Colonna, M M.. (2001) TREM-1 amplifies inflammation and is a crucial mediator of septic shock.. Nature, (26): [PMID:11323674] |
| 5. Gingras, Marie-Claude MC, Lapillonne, Hélène H and Margolin, Judith F JF.. (2002) TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development.. Molecular immunology, [PMID:11922939] |
| 6. Radaev, Sergei S, Kattah, Michael M, Rostro, Bertha B, Colonna, Marco M and Sun, Peter D PD.. (2003) Crystal structure of the human myeloid cell activating receptor TREM-1.. Structure (London, England : 1993), [PMID:14656437] |
| 7. Kelker, Matthew S MS and 6 more authors.. (2004) Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A.. Journal of molecular biology, (24): [PMID:15351648] |
| 8. Sjöblom, Tobias T and 28 more authors.. (2006) The consensus coding sequences of human breast and colorectal cancers.. Science (New York, N.Y.), (13): [PMID:16959974] |
| 9. Arts, Rob J W RJ and 5 more authors.. (2011) TREM-1 interaction with the LPS/TLR4 receptor complex.. European cytokine network, [PMID:21393102] |
| 10. Ormsby, Tereza T and 11 more authors.. (2011) Btk is a positive regulator in the TREM-1/DAP12 signaling pathway.. Blood, (28): [PMID:21659545] |
| 11. Read, Christine B CB and 14 more authors.. (2015) Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:25595774] |
| 12. Baruah, Sankar and 6 more authors.. (2015) Identification of a Novel Splice Variant Isoform of TREM-1 in Human Neutrophil Granules.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:26561551] |
| 13. Carrasco, Kevin K and 12 more authors.. (2019) TREM-1 multimerization is essential for its activation on monocytes and neutrophils.. Cellular & molecular immunology, [PMID:29568119] |
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