Measured by its ability to inhibit BMP-6-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 4-16 μg/mL in the presence of 100 ng/mL of Recombinant Human BMP-6.
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
生物活性
Measured by its ability to inhibit BMP-6-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 4-16 μg/mL in the presence of 100 ng/mL of Recombinant Human BMP-6.
Recombinant Human Twisted Gastrulation/TSG Protein (rp152830) - SDS-PAGE
2 μg/lane of Recombinant Human Twisted Gastrulation/TSG Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 30 - 40 kDa.
ZJ26F0332645
危险品化学品经营许可证（带存储）