Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses.
生物活性
Immobilized Recombinant Mouse CD80 at 500ng/mL (100 μL/well) can bind Recombinant Human CTLA-4 with a linear range of 10-50 ng/mL.
Recombinant Mouse B7-1/CD80 Protein (rp153775) - SDS-PAGE 2 μg/lane of Recombinant Mouse B7-1/CD80 Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing the band at 40 - 55 & 100 kDa under reducing conditions.
ZJ25F0724870
危险品化学品经营许可证（带存储）