Measured by its ability to inhibit IL-1 alpha -dependent proliferation in D10.G4.1 mouse helper T cells. Approximately 0.005‑0.015 µg/mL of IL-1 sRI will inhibit 50% of the biological response due to 50 pg/mL of rmIL-1a.
Function Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.
规格
产品名称
Recombinant Mouse IL-1 RI Protein
别名
重组小鼠IL-1 RI蛋白 | 重组小鼠白介素1受体Ⅰ蛋白
英文别名
Interleukin 1 Receptor I | CD121 antigen-like family member A | CD121a antigen | CD121a | IL-1 RI | IL1R | IL1R1 | IL1RI | IL1RT1 | IL-1RT1 | IL-1RT-1 | Interleukin 1 Receptor 1 | interleukin 1 receptor, type I | interleukin receptor 1 | interleukin-1 rec
Measured by its ability to inhibit IL-1 alpha -dependent proliferation in D10.G4.1 mouse helper T cells. Approximately 0.005‑0.015 µg/mL of IL-1 sRI will inhibit 50% of the biological response due to 50 pg/mL of rmIL-1a.
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。复溶后建议分装。避免冷冻/解冻循环。
图片
Recombinant Mouse IL-1 RI Protein (rp154122) - SDS-PAGE 2 μg/lane of Recombinant Mouse IL-1 RI Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing the band at 50 - 55 kDa under reducing conditions.
ZJ25F0522118
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