Purity ≥95% SDS-PAGE. Endotoxin level <0.1 EU/µg Function Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an ""alarmin"", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).
规格
产品名称
Recombinant Mouse IL-33 Protein
别名
重组小鼠IL-33蛋白 | 重组小鼠白介素33蛋白
英文别名
Interleukin 33 | C9orf26 | chromosome 9 open reading frame 26 (NF-HEV) | DKFZp586H0523 | DVS27 | DVS27-related protein | IL1F11 | IL-1F11 | IL33 | IL-33 | Interleukin-1 family member 11 | interleukin-33 | NFHEV | NF-HEV | NFEHEV | Nuclear factor from high
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。复溶后建议分装。避免冷冻/解冻循环。
图片
Recombinant Mouse IL-33 Protein (rp154210) - SDS-PAGE 2 μg/lane of Recombinant Mouse IL-33 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 16 -18 kDa under reducing conditions and 16 -18 & 32 kDa under non-reducing conditions due to glycosylation.
Recombinant Mouse IL-33 Protein (rp154210) - Protein Bioactivity
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED₅₀ for this effect is 0.15 ng/mL.
ZJ25F0928139
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