计算溶液所需的质量、体积或浓度。
Recombinant Mouse IL-36 alpha/IL-1F6 Protein (rp154218)-Protein Bioactivity
Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED₅₀ for this effect is <18 ng/mL.
ActiBioPure™,His标签,无动物源,无叠氮钠,无载体,生物活性,高性能 级 提供 ≥95%(SDS-PAGE) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Purity
>95% SDS-PAGE.
IL‑36 alpha is mainly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine. It is expressed by monocytes, B and T cells. The receptor for IL‑36 alpha is a combination of IL‑1 Rrp2 (also called IL‑1 RL2 or IL‑1 R6), mainly found in epithelia and keratinocytes, and the widely expressed IL‑1 RAcP. IL‑36 alpha, beta and gamma all activate NF‑ kappa B and MAPK pathways in an IL‑1 Rrp2 dependent manner, and induce production of inflammatory cytokines and chemokines such as CXCL8/IL‑8. IL‑36 alpha and other family members are overexpressed in psoriatic skin lesions, and transgenic overexpression of IL‑36 alpha in skin keratinocytes produces epidermal hyperplasia. IL‑36 alpha is present in kidney tubule epithelia; it is highly overexpressed in tubulointerstitial lesions in mouse models of chronic glomerulonephritis, lupus nephritis and diabetic nephritis. IL‑36 alpha is induced by inflammation in adipose tissue‑resident alternately activated (M2) macrophages, and reduces adipocyte differentiation.
Recombinant Mouse IL-36 alpha/IL-1F6 Protein (rp154218)-Protein Bioactivity
Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED₅₀ for this effect is <18 ng/mL.
Recombinant Mouse IL-36 alpha/IL-1F6 Protein (rp154218)-SDS-PAGE
2μg/lane Recombinant Mouse IL-36 alpha/IL-1F6 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a single band at 15.5 kDa.
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | rp154218 | |
| 分析证书 | rp154218 | |
| 分析证书 | rp154218 | |
| 分析证书 | rp154218 |
我们的级别选择指南涵盖了目录中所有的变体的纯度、稳定剂状态和应用适用性。
查看 Animal Free 级别指南 → 查看 Carrier Free 级别指南 → 查看 Bioactive 级别指南 → 查看 ActiBioPure™ 级别指南 → 查看 Azide Free 级别指南 → 查看 High Performance 级别指南 → 查看 His Tag 级别指南 →