ActiBioPure™,His标签,PBS Only,无动物源,无载体,生物活性 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining.
Description：
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) - SDS-PAGE
3 μg/lane of Recombinant Human SARS-CoV-2 Spike Protein RBD was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining. Showing a band at 36.4 kDa under reducing conditions and 34.2 kDa under non-reducing conditions.
Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) - ELISA
Immobilized Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) at 1.0 μg/mL can bind Regdanvimab (anti-Spike RBD) (Ab182925) with the EC₅₀ of 12.65 ng/mL.
Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) - ELISA
Immobilized Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) at 1.0 μg/mL can bind Imdevimab (anti-Spike RBD) (Ab182897) with the EC₅₀ of 7.82 ng/mL.
Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) - ELISA
Immobilized Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) at 1.0 μg/mL can bind Etesevimab (anti-Spike RBD) (Ab182932) with the EC₅₀ of 23.96 ng/mL.
Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) - ELISA
Immobilized Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) at 1.0 μg/mL can bind Sotrovimab (anti-Spike RBD) (Ab182938) with the EC₅₀ of 41.33 ng/mL.
Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) - ELISA
Immobilized Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) at 1.0 μg/mL can bind Casirivimab (anti-Spike RBD) (Ab182896) with the EC₅₀ of 10.50 ng/mL.
Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) - ELISA
Immobilized Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) at 1.0 μg/mL can bind Cilgavimab (anti-Spike RBD) (Ab182901) with the EC50 of 173.8 ng/mL.
Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) - Binding Activity
Immobilized Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) at 5.0 μg/mL can bind Recombinant Human ACE-2 Protein (rp176242) with the EC₅₀ of 75.79 ng/mL.
Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) - ELISA
Immobilized Recombinant Human SARS-CoV-2 Spike Protein RBD protein (rp155929) at 1.0 μg/mL can bind Bebtelovimab (anti-Spike RBD) (Ab175465) with the EC
₅₀
of 32.26 ng/mL.
Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) - ELISA
Immobilized Recombinant Human SARS-CoV-2 Spike Protein RBD (rp155929) at 1.0 μg/mL can bind Bamlanivimab (anti-Spike RBD) (Ab182908) with the EC₅₀ of 22.45 ng/mL.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0202907 |
分析证书 | rp155929 |
| ZJ24F0202908 |
分析证书 | rp155929 |
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