SOX2 is a member of the SOXB1 subfamily of transcription factors most notably involved in the reprogramming of somatic cells into induced pluripotent stem cells. Housed on chromosome 3, the SOX2 gene encodes for a protein with a C-terminal transcriptional activation domain and a DNA-binding HMG domain that contains a nuclear localization/export signal. SOX2 forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development and pluripotency such as YES1, FGF4, UTF1 and ZFP206. Mutations in this gene have been associated with bilateral eye disease. SOX2 antigen and antibody were found in small-cell lung cancer cell lines and sera. However, neither exists in normal sera, suggesting that SOX2 might be a potential tumor target or marker.
规格
产品名称
Recombinant Human SOX2 Protein
别名
重组人SOX2蛋白 | 重组人 SOX2 蛋白
英文别名
cb236 | Delta EF2a | Lcc | MCOPS3 | MGC148683 | MGC2413 | RGD1565646 | Sex determining region Y box 2 | ANOP3 | SOX 2 | Sox2 | SOX2_HUMAN | SRY (sex determining region Y) box 2 | SRY box containing gene 2 | SRY related HMG box 2 | SRY related HMG box gene
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
图片
Recombinant Human SOX2 Protein (rp156646) - SDS-PAGE 3 μg/lane of Recombinant Human SOX2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 37.3 kDa.
ZJ24F0809455
危险品化学品经营许可证（带存储）