General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
Recombinant Human TATA binding Protein (rp156667) - SDS-PAGE 3 μg/lane of Recombinant Human TATA binding Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 60.0 &132.5 kDa. The monomer of TBP adopts a symmetrical saddle-shaped structure, which binds to the TATA box of DNA via its concave surface. This symmetry may facilitate the formation of a dimer between two monomers through hydrogen bonds or hydrophobic interactions between β-sheets (PubMed: 7775442).
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